They point out: “When Sheldon goes to see the medium, the one where Penny (Kaley Cuoco) forces him to go to see how to reveal his future in science,
“She says ‘to unlock his future he needs to get closed to his girlfriend.’She actually predicted the truth!!! Just noticed it.”
Therefore, once Sheldon had teamed up with Amy, eagle-eyed fans should’ve foreseen a Nobel Prize on the horizon.
The fan may be onto something as the scene in question is rather telling to Sheldon’s eventual outcome.